About CYTOCON DB Open
CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.
CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.
CYTOCON DB is accessible via purchasing the commercial license. You can visit www.cytocon.insysbio.com for more details. CYTOCON DB Open is reduced and free version of CYTOCON DB designed for public use. CYTOCON DB Open differs from CYTOCON DB in content and functional features of both front and back ends.
Both content and functionality of CYTOCON DB Open will be updated once per year.
Key features of CYTOCON DB Open:
- Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
- Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
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Search query may include following patient group attributes:
- demographic characteristics (age, race, gender, etc);
- number of patients in the study.
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Search query may take into account disease-specific clinically measured characteristics, for example:
- Asthma: FEV1;
- SLE: SLEDAI range, interferon signature;
- Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
- etc.
- Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
- Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
- Graphic representation of search results: average value, dispersion, source.
- Export of search results in csv format
Content of CYTOCON DB Open version:
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- 1,2-Diacyl-sn-glycero-3-phosphocholine
- 12-hydroxyeicosatetraenoic acid (12-HETE)
- 13,14-dihydro-15-keto Prostaglandin E1 (PGE1)
- 15-hydroxyeicosatetraenoic acid (15-HETE)
- 15-keto-13,14-dihydroprostaglandin E2
- 25-hydroxyvitamin D (25(OH)D)
- 5-hydroxyeicosatetraenoic acid (5-HETE)
- 6-Keto-Prostaglandin F1α (6-Keto-PGF1α)
- 8-Hydroxy-2'-deoxyguanosine (8-OHdG)
- 8-isoprostane
- 9a,11b-Prostaglandin F2 (9a,11b-PGF2)
- Abeta42
- Adenosine deaminase (ADA)
- Adiponectin
- Adipsin
- Adrenocorticotropic hormone (ACTH)
- Alanine aminotransferase 1
- Albumin
- ALP (Alkaline phosphatase)
- Alpha-1 globulin
- Alpha1-fetoprotein transcription factor short variant
- Alpha-2 globulin
- Alpha-2-antiplasmin
- Alpha2-antiplasmin (A2PI)
- Alpha-2-macroglobulin
- Alpha-Tocopherol
- Alprostadil
- Amylase
- Angiopoietin-2
- Angiostatin
- anti-HBc
- Anti-SEA IgE (anti-staphylococcus enterotoxin A)
- Anti-SEB IgE (anti-staphylococcus enterotoxin B)
- ApoA-II
- ApoA-IV
- ApoB
- ApoC-III
- ApoE
- Apolipoprotein A-I
- APRIL
- Arachidonic Acid
- Arginase-1
- Ascorbic acid
- Aspartate aminotransferase (AST)
- Axl (tyrosine-protein kinase 7)
- BAFF
- BAMBI
- Beta-2-microglobulin
- Betacellulin (BTC)
- Beta-globulin
- b-FGF (basic fibroblast growth factor, FGF2)
- Bilirubin direct
- Bilirubin indirect
- Bilirubin total
- Blood urea nitrogen
- Brain natriuretic peptide (BNP)
- Brain-derived neurotrophic factor (BDNF)
- C1s inactivator
- C3 PA (properdin factor B)
- C3c (Complement component 3c)
- C3d (Complement component 3d)
- C4 (Complement component 4)
- CA125 (cancer antigen 125)
- CA12-5 (cancer antigen 12-5)
- CA15-3 (cancer antigen 15-3)
- CA19-9 (cancer antigen 19-9)
- Carbamide
- Carcinoembryonic antigen (CEA)
- Cardiac Troponin I (cTnI)
- Cathelicidin (LL-37)
- C-C motif chemokine 14
- C-C motif chemokine 18
- cccDNA
- CCL1 [C-C motif chemokine Ligand 1]
- CCL11
- CCL13
- CCL15
- CCL16 (HCC-4)
- CCL17
- CCL19
- CCL2
- CCL20
- CCL21
- CCL22
- CCL23
- CCL24
- CCL25
- CCL26
- CCL27
- CCL28
- CCL3
- CCL4
- CCL5 [C-C motif chemokine Ligand 5]
- CCL7
- CCL8
- CCP (Cyclic Citrullinated Peptide) antibodies
- CD40 ligand
- CGRP [Calcitonin Gene Related Protein]
- Chitinase-3-like protein 1 (YKL-40)
- Cholesterol
- Cholesteryl ester
- Cholinesterase (butyrylcholinesterase)
- Citrate
- CKMB (creatine kinase isoenzyme)
- Collagen alpha-1(III) chain
- Collagen alpha-3(IV) chain
- Complement C1q subcomponent subunit A
- Complement C1s subcomponent
- Complement C2
- Complement C3
- Complement component C9
- Complement factor B
- C-reactive protein (CRP)
- Creatine kinase
- Creatinine
- Cryptoxanthin
- C-telopeptide
- CX3CL1
- CXCL1
- CXCL10
- CXCL11
- CXCL12a [C-X-C motif chemokine Ligand 12 alpha]
- CXCL13
- CXCL16
- CXCL2
- CXCL3
- CXCL4
- CXCL5
- CXCL6
- CXCL7
- CXCL9
- CYFRA 21.1
- Cystatin C (CysC)
- Cysteinyl leukotrienes (Cys-LTs)
- Cytokeratin18 (CK18)
- D-dimer (fibrin degradation product)
- DGLA (dihomo-gamma linolenic acid)
- DHA (Docosahexaenoic acid)
- Dinoprostone
- DPA (Docosapentaenoic acid)
- ECP [Eosinophil Cationic Protein]
- Elafin
- Elastin-derived peptide
- EMMPRIN (CD147)
- Endotoxin
- Eosinophil protein Х (EPX)
- EPA (Eicosapentaenoic acid)
- Epidermal Growth Factor (EGF)
- Ferritin
- Fibrin
- Fibrin Degradation Products (FDP)
- Fibrinogen
- Fibroblast growth factor 1
- Fibroblast growth factor 2
- FLCs kappa
- FLCs lambda
- Flt3‑L
- Follistatin
- Free Choline
- Free Fatty acids (FFA)
- Free Glycerol
- Gamma-globulin
- gamma-Glutamyl Transpeptidase (GGT)
- GCSF [Granulocyte Colony-Stimulating Factor]
- GH (growth hormone/somatotropin)
- Glial cell-derived neurotrophic factor (GDNF)
- Globulin
- Glucose
- Glutathione
- Glutathione peroxidase 1
- Glycoprotein 130 (gp130)
- Glycyl-proline-dipeptidyl aminopeptidase (GPDA)
- GMCSF [Granulocyte-Macrophage Colony-Stimulating Factor]
- GranzymeA
- GranzymeB
- GRO [Growth-Related Oncogene]
- Guanosine Monophosphate
- H2O2
- Haptoglobin
- hBD-2 (human β-defensin 2)
- hBD-3 (human β-defensin 3)
- HBeAg
- HBsAg
- HBV DNA
- HBV RNA
- HCV RNA
- HDL-cholesterol
- HDL-unesterified cholesterol
- HE4 (Human epididymis protein 4)
- Hemoglobin
- Hepatitis A virus cellular receptor 2
- Hepatocyte growth factor (HGF)
- High mobility group box 1 (HMGB1, amphoterin)
- high sensitive troponin I (hsTnI)
- Hippurate
- Histamine
- HNPs (human neutrophil peptides, defensins)
- Hydrocortisone
- ICAM
- IFNb
- IgA
- IgE
- IGF-1 (insulin growth factor 1)
- IGFBP-2 (insulin like growth factor binding protein 2)
- IGFBP-3
- IgG
- IgG1
- IgG2
- IgG3
- IgG4
- IgM
- IL1
- IL10
- IL11
- IL12
- IL12a (IL12p35)
- IL12b (IL23p40)
- IL12p70
- IL13
- IL15
- IL16
- IL17
- IL17a
- IL17af
- IL17F
- IL18
- IL18 BPa
- IL18BP (Interleukin-18 Binding Protein)
- IL19
- IL1a
- IL1b
- IL1RAcP
- IL1RL1 [Interleukin 1 Receptor Like 1]
- IL2
- IL20
- IL21
- IL22
- IL23 (p19/p40)
- IL23p19 (IL23a)
- IL24
- IL25
- IL26
- IL27
- IL28a
- IL29
- IL2R
- IL2Ra (sCD25)
- IL3
- IL31
- IL32
- IL33
- IL34
- IL35
- IL36
- IL37
- IL4
- IL5
- IL6
- IL7
- IL8
- IL9
- Immune complexes (IC)
- Immunoreactive LTC4 (iLTC4)
- Insulin
- Interferon (IFN)
- Interferon alpha-1/13
- Interferon alpha-2
- Interferon gamma
- Interleukin-1 receptor accessory protein
- Interleukin-1 receptor antagonist protein
- Interleukin-1 receptor type 1
- Interleukin-1 receptor type 2
- Interleukin-18 receptor 1
- Interleukin-2 receptor subunit alpha
- Interleukin-7 receptor subunit alpha
- Iron
- ischemia-modified albumin (IMA)
- Keratinocyte growth factor
- KL-6
- Kynurenine
- Lactate
- Lactate dehydrogenase
- Laminin subunit gamma-1
- LDL-cholesterol
- Leptin
- Leucine-rich alpha-2-glycoprotein
- LIF (leukemia inhibitory factor)
- LIGHT (TNFSF14, CD258)
- Linoleic Acid
- Linolenic Acid
- Lipase
- Lipocalin-2
- LTB4
- LTC4
- LTD4
- LTE4
- Lymphotoxin-alpha
- Lysozyme C
- Malondialdehyde
- MAO [Monoamine Oxidase]
- Mast cell chymase
- Mast cell tryptase
- MCSF
- Meteorin-like protein
- MIF
- MMP1
- MMP10
- MMP12
- MMP13
- MMP2
- MMP7
- MMP8
- MMP9
- MSPa (macrophage stimulating protein a)
- MUFA (Monounsaturated Fatty Acids)
- Myeloperoxidase (MPO)
- Myoglobin
- Neopterin
- Neurofilament light chain
- Neuron-specifc enolase (NSE)
- Neuropeptide Y
- Neutrophil elastase
- NGF [Nerve Growth Factor]
- NGF-beta (beta-nerve growth factor)
- NLRP3 (Nod-like receptor protein 3 inflammasome)
- NO [Nitric Oxide]
- Nonesterified Fatty Acid (NEFA)
- Non-HDL-unesterified cholesterol
- NT-proBNP (N-terminal brain natriuretic peptide)
- Oleic Acid
- Oncostatin-M
- ONOO (Peroxynitrite)
- Osteocalcin
- Osteopontin (OPN)
- Oxiglutatione
- PARC (recombinant human MIP-4)
- PC-III (type III pre-collagen)
- PDGF-AA
- PDGF-BB [Platelet Derived Growth Factor-BB]
- Pentraxin-3
- Perforin
- Periostin
- PINP (amino-terminal propeptide of procollagen type I)
- Plasminogen
- Plasminogen activator inhibitor-1 (PAI-1)
- Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)
- Platelet-Activating Factor (PAF)
- Platelet-derived growth factor subunit A
- Pleiotrophin (PTN)
- PlGF-1 (Placental growth Factor 1)
- Prealbumin
- pro-BNP (pro-B-type natriuretic peptide)
- Procalcitonin
- Procollagen-3
- Prolactin (PRL)
- Prostaglandin D2 (PGD2)
- Prostaglandin F2b (PGF2b)
- Prostaglandin F2α (PGF2α)
- Prostate-specific antigen
- Protein carbonyls
- Protein total
- P-tau (phosphorylated tau)
- PUFA (Polyunsaturated Fatty Acids)
- Pulmonary surfactant-associated protein A1
- Resistin
- Retinol-binding protein (RBP)
- RF (Rheumatoid Factor)
- RF-IgM
- RIPK1 (receptor-interacting protein kinase-1)
- sAbetaPPbeta
- sCD163
- sCD23
- sCD27
- sCD30
- SCGF-b (Stem Cell Growth Factor beta)
- sc-kit (SCFR)
- Secretory Leukocyte Protease Inhibitor (SLPI)
- Selenium
- Serpin B3
- Serum amyloid A
- SFA (Saturated Fatty Acids)
- Sgp130 (Soluble Glycoprotein 130)
- sIL1R4 (Soluble Interleukin-1 Receptor-4)
- sIL2R
- sIL6R
- sILT3
- SP-40,40 (clusterin)
- Sphingomyelin
- sP-selectin
- sST2 (Soluble suppression of tumorigenicity-2)
- Stem Cell Factor (SCF)
- sTNF-R1
- sTNF-R2
- sTREM2 (soluble triggering receptor expressed on myeloid cells 2)
- Stromal cell-derived factor 1
- Stromelysin-1
- Substance P (SP)
- SuperOxide Dismutase (SOD)
- Surfactant protein D (SP-D)
- sVEGFR1
- sVEGFR2
- Taurine
- TGFa
- TGFb
- TGF-beta receptor type-1
- TGF-beta receptor type-2
- Thioredoxin 1 (TRX1)
- Thrombin-antithrombin complex (TAT)
- Thrombopoietin (TPO, MGDF)
- Thromboxane B2 (TXB2)
- Thyroglobulin (TG)
- TIMP1
- TIMP2
- Tissue factor
- Tissue Plasminogen Activator (tPA)
- Tissue plasminogen activator (tPA)/plasminogen activator inhibitor type I (PAI) complex (tPA/PAI)
- TL1A (TNFSF15)
- TNFR1
- TNTHSST (high-sensitivity troponin T)
- Total bile acid (TBA)
- Total cholesterol
- TRAIL (TNF-related apoptosis-inducing ligand)
- Transferrin
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Transforming growth factor beta-3 proprotein
- Triglyceride
- Triglycerides
- Troponin
- Troponin I
- Troponin T
- Tryptase
- TSLP
- T-tau (total tau)
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 6
- Tumor necrosis factor receptor superfamily member 6
- TWEAK
- Unesterified cholesterol
- Urate
- Urokinase-type plasminogen activator (uPA)
- VAP-1 (vascular adhesion protein-1)
- VCAM-1 (vascular cell adhesion molecule-1)
- VEGF [Vascular Endothelial Growth Factor]
- VEGF-A
- VEGF-C
- VEGF-D
- VIP [Vasoactive Intestinal Peptide]
- Vitamin A
- XCL1
- α-hydroxybutyrate dehydrogenase (α-HBDH)
- α-L-fucosidase
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- 35113 values of cytokine/cell concentrations;
- data extracted from 970 papers/other public sources.
CYTOCON DB Open is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.
Access to Cytocon DB Open
To start working with CYTOCON DB Open please register an account:
Register account
e-mail for correspondence: support@insysbio.com
