Cytocon DB Open

About CYTOCON DB Open


CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.

CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies. 

CYTOCON DB is accessible via purchasing the commercial license. You can visit www.cytocon.insysbio.com for more details. CYTOCON DB Open is reduced and free version of CYTOCON DB designed for public use. CYTOCON DB Open differs from CYTOCON DB in content and functional features of both front and back ends.

Both content and functionality of CYTOCON DB Open will be updated once per year.

Key features of CYTOCON DB Open:

  • Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
  • Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
  • Search query may include following patient group attributes:
    • demographic characteristics (age, race, gender, etc);
    • number of patients in the study.
  • Search query may take into account disease-specific clinically measured characteristics, for example:
    • Asthma: FEV1;
    • SLE: SLEDAI range, interferon signature;
    • Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
    • etc.
  • Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
  • Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
  • Graphic representation of search results: average value, dispersion, source.
  • Export of search results in csv format

Content of CYTOCON DB Open version:

    • Acinic cell adenocarcinoma
    • Acute allergic reactions
    • Adenocarcinoma of bronchus or lung
    • Adenocarcinoma of oesophagus
    • Adenocarcinoma of stomach
    • Adenoid cystic carcinoma
    • Adult T-cell leukaemia/lymphoma (ATLL)
    • Alcohol-induced dementia
    • Allergic asthma
    • Allergic contact dermatitis
    • Allergic rhinitis
    • Alveolar rhabdomyosarcoma
    • Alveolar soft part sarcoma
    • Alzheimer disease
    • Angiosarcoma
    • Ankylosing spondylitis
    • Asthma
    • Atopic allergy
    • Atopic asthma
    • Atopic dermatitis
    • Atopy, nonasthma
    • Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy
    • Bacterial pneumonia
    • B-cell non-Hodgkin lymphoma (B-NHL)
    • Behçet's disease
    • Benign lung lesions
    • Benign soft-tissue neoplasm
    • Brain trauma
    • Bronchial asthma
    • Bronchiectasis
    • Bronchoalveolar carcinoma
    • Bullous pemphigoid
    • Carcinoma
    • CD40L deficiency
    • Central nervous system infection
    • Cerebrovascular disease no-dementia
    • Chondrosarcoma
    • Chordoma
    • Chronic atrophic gastritis
    • Chronic bronchitis (COPD)
    • Chronic cough
    • Chronic idiopathic urticaria, hives
    • Chronic kidney disease
    • Chronic obstructive pulmonary disease (COPD)
    • Chronic Spontaneous Urticaria
    • Clear cell sarcoma
    • Colitis
    • Colitis associated cancer (CAC)
    • Colorectal cancer
    • Contact dermatitis
    • COVID-19
    • Crohn's disease
    • Cutaneous Lupus Erythematosus
    • Cutaneous T-cell lymphoma
    • Cystic fibrosis
    • Dedifferentiated liposarcoma
    • Deep vein thrombosis
    • Dementia with Lewy bodies (DLB)
    • Depression (6A70.Z Single episode depressive disorder)
    • Dermatomyositis
    • Dermatophytosis
    • Desmoplastic small round cell tumour
    • DFSP dermatofibrosarcoma protuberans
    • Discoid Lupus Erythematosus
    • Dysbacteriosis
    • Embryonal rhabdomyosarcoma
    • End stage renal disease
    • Eosinophilia
    • Eosinophilic asthma
    • Eosinophilic bronchitis
    • Epithelioid sarcoma
    • Esophageal carcinoma
    • Ewing sarcoma
    • Familial lecithin:cholesterol acyltransferase (LCAT) deficiency
    • Familial lipoprotein lipase (LPL) deficiency
    • Focal segmental glomerulosclerosis
    • Frontotemporal lobe dementia (FTLD)
    • Gastric cancer
    • Gastric ulcer
    • GIST gastrointestinal stromal tumour
    • Healthy control
    • IgA glomerulonephriris
    • Infections
    • Inflammatory Bowel Diseases
    • Irritable Bowel Syndrome
    • Large cell carcinoma of bronchus or lung
    • Leiomyosarcoma
    • Low-grade fibromyxoid sarcoma
    • Lung cancer
    • Lupus nephritis
    • Malignant salivary gland tumors
    • Melanoma
    • Membranous nephropathy
    • Mild cognitive impairment with Alzheimer’s disease (MCI-AD)
    • Mild cognitive impairment with Lewy body dementia (MCI-LB)
    • MPNST malignant peripheral nerve sheath tumor
    • Mucoepidermoid carcinoma
    • Myasthenia gravis
    • Myxofibrosarcoma
    • Myxoid/round cell liposarcoma (MRCL)
    • Neutrophilic asthma
    • Nocturnal Asthma
    • Non-Hodgkin Lymphoma
    • Non-Small Cell Lung Cancer (NSCLC)
    • Non-squamous bronchial carcinoma
    • Non-translocation sarcoma
    • Nummular Eczema
    • Obesity
    • Osteosarcoma
    • Paucigranulocytic asthma
    • Pemphigus vulgaris
    • Pleomorphic adenoma
    • Primary bronchial carcinoma
    • Psoriasis
    • Pulmonary embolism
    • Pulmonary emphysema
    • Refractory Bone and Soft Tissue Sarcoma
    • Renal carcinoma
    • Renal dysfunction
    • Rheumatoid arthritis
    • Sarcoidosis
    • Sarcoma
    • Sclerodermia
    • Seborrheic dermatitis
    • Sepsis
    • Septic shock
    • Small cell carcinoma of bronchus or lung
    • Soft tissue sarcoma
    • Solid malignant tumors
    • Solitary fibrous tumor
    • Sporadic colorectal cancer (CRC)
    • Squamous cell carcinoma of bronchus or lung
    • Squamous cell carcinoma of oesophagus
    • Stat3-Hyper-IgE syndrome
    • Synovial sarcoma
    • System indolent mastocytosis
    • Systemic lupus erythematosus
    • Thyroid cancer
    • Translocation-associated sarcoma
    • Tuberculosis
    • Ulcerative colitis
    • UPS undifferentiated pleomorphic sarcoma
    • Vascular dementia
    • Viral meningoencephalitis
    • Wegener’s granuloma
    • Well-differentiated liposarcoma
    • Сhronic superficial gastritis
    • Airway (bronchial) epithelium
    • Airway lamina propria
    • Airway smooth muscle
    • Basement membrane of epidermis
    • Basement membrane of epidermis lesional
    • Basement membrane of epidermis nonlesional
    • Benign lung lesion homogenates
    • Blood
    • Blood arterial
    • Blood from tumor
    • Bone marrow
    • Bronchial glands
    • Bronchial mucosa
    • Bronchial subepithelial tissue
    • Bronchial submucosa
    • Bronchial tissue
    • Bronchial wash
    • Bronchoalveolar carcinoma tumor tissue
    • Broncho-alveolar lavage (BAL)
    • Cerebrospinal fluid (CSF)
    • Colon
    • Colonic lamina propria
    • Coproextracts
    • Dermis
    • Dermis papillary
    • Dermis papillary lesional
    • Dermis papillary nonlesional
    • Dermis upper
    • Dermis upper lesional
    • Dermis upper nonlesional
    • Endobronchial (airway) biopsies
    • Epidermis
    • Esophageal tumor tissue lysate
    • Exhaled Breath Condensate
    • Gastric tissue
    • Gastric tumor tissue
    • Induced Sputum
    • Intratumor soft tissue of synovial sarcoma
    • Invasive margin of tumor soft tissue of synovial sarcoma
    • Lesional dermis
    • Lesional epidermis
    • Lesional skin
    • Lung adenocarcinoma tumor tissue
    • Lung cancer tissue
    • Lung tissue
    • Lymph
    • Lymph node
    • Melanoma peritumoral tissue
    • Melanoma tumor tissue
    • Non-lesional dermis
    • Non-lesional epidermis
    • Non-lesional skin
    • NSCLC peritumoral tissue
    • NSCLC tumor islets (nests)
    • NSCLC tumor stroma
    • NSCLC tumor tissue
    • Pericardial effusion
    • Peripheral bronchial biopsy specimens
    • Peritoneum
    • Plasma
    • Plasma arterial
    • Plasma from cord blood
    • Pleural effusion
    • Serum
    • Serum from tumor
    • Skin
    • Small intestine
    • Sputum
    • Squamous cell carcinoma tumor tissue
    • Stroma region of colon
    • Suction Blister Fluids
    • Transbronchial (alveolar tissue) biopsies
    • Tumor
    • Tumor region of colon
    • Urine
    • 12-hydroxyeicosatetraenoic acid (12-HETE)
    • 15-hydroxyeicosatetraenoic acid (15-HETE)
    • 25-hydroxyvitamin D (25(OH)D)
    • 5-hydroxyeicosatetraenoic acid (5-HETE)
    • 6-Keto-Prostaglandin F1α (6-Keto-PGF1α)
    • 8-isoprostane
    • 9a,11b-Prostaglandin F2 (9a,11b-PGF2)
    • Abeta42
    • Adiponectin
    • Adipsin
    • ALA (alpha-linolenic acid)
    • Albumin
    • Alpha-1 antitrypsin
    • Alpha2-antiplasmin (A2PI)
    • Alpha2-macroglobulin (a2M)
    • Angiostatin
    • Anti-SEA IgE (anti-staphylococcus enterotoxin A)
    • Anti-SEB IgE (anti-staphylococcus enterotoxin B)
    • ApoA-I
    • ApoA-II
    • ApoA-IV
    • ApoB
    • ApoC-III
    • ApoE
    • APRIL
    • Arachidonic Acid
    • Axl (tyrosine-protein kinase 7)
    • BAFF
    • Betacellulin (BTC)
    • b-FGF (basic fibroblast growth factor, FGF2)
    • Bilirubin total
    • Blood urea nitrogen
    • Brain-derived neurotrophic factor (BDNF)
    • C1q (Complement component 1q)
    • C1s (Complement component 1s)
    • C1s inactivator
    • C2 (Complement component 2)
    • C3 (Complement component 3)
    • C3 PA (properdin factor B)
    • C3c (Complement component 3c)
    • C3d (Complement component 3d)
    • C4 (Complement component 4)
    • C9 (Complement component 9)
    • CA19-9 (cancer antigen 19-9)
    • Calcitonin Gene Related Protein (CGRP)
    • Carcinoembryonic antigen (CEA)
    • Cardiac Troponin I (cTnI)
    • CCL1
    • CCL11
    • CCL13
    • CCL14 (HCC-1)
    • CCL16 (HCC-4)
    • CCL17
    • CCL18
    • CCL19
    • CCL2
    • CCL20
    • CCL21
    • CCL22
    • CCL23
    • CCL24
    • CCL25
    • CCL26
    • CCL27
    • CCL28
    • CCL3
    • CCL4
    • CCL5
    • CCL7
    • CCL8
    • CCP (Cyclic Citrullinated Peptide antibody)
    • Chitinase-3 like 1
    • Cholesterol
    • Cholesteryl ester
    • Citrate
    • Complement factor B
    • C-reactive protein (CRP)
    • Creatinine
    • CX3CL1 (fractalkine)
    • CXCL1
    • CXCL10
    • CXCL11
    • CXCL12
    • CXCL12a (SDF-1a)
    • CXCL13
    • CXCL16
    • CXCL2
    • CXCL4
    • CXCL5
    • CXCL6
    • CXCL7
    • CXCL9
    • CYFRA 21.1
    • Cystatin C (CysC)
    • Cysteinyl leukotrienes (Cys-LTs)
    • Cytokeratin18 (CK18)
    • D-dimer (fibrin degradation product)
    • DGLA (dihomo-gamma linolenic acid)
    • DHA (Docosahexaenoic acid)
    • DNAse1
    • DNAse1L3
    • DPA (Docosapentaenoic acid)
    • Elafin
    • Elastin-derived peptide
    • Endotoxin
    • Eosinophil Cationic Protein (ECP)
    • Eosinophil protein Х (EPX)
    • EPA (Eicosapentaenoic acid)
    • Epidermal Growth Factor (EGF)
    • Fas
    • FasL
    • Ferritin
    • FGF
    • FGF-2 ( fibroblast growth factor 2)
    • Fibrin
    • Fibrinogen
    • Free Choline
    • Free Glycerol
    • Gamma-globulin
    • GCSF (Granulocyte colony-stimulating factor)
    • GH (growth hormone/somatotropin)
    • Glial cell-derived neurotrophic factor (GDNF)
    • Globulin
    • Glucose
    • Glycoprotein 130 (gp130)
    • GMCSF
    • GranzymeB
    • Growth-related oncogene (GRO)
    • GSH (reduced glutathione)
    • GSSG (oxidised glutathione)
    • H2O2
    • hBD-2 (human β-defensin 2)
    • hBD-3 (human β-defensin 3)
    • HDL-cholesterol
    • HDL-unesterified cholesterol
    • HE4 (Human epididymis protein 4)
    • Hemoglobin
    • Hepatocyte growth factor (HGF)
    • High mobility group box 1 (HMGB1, amphoterin)
    • Hippurate
    • Histamine
    • I-309
    • ICAM
    • IFNb
    • IFNg
    • IgA
    • IgE
    • IGF-1 (insulin growth factor 1)
    • IGFBP-2 (insulin like growth factor binding protein 2)
    • IGFBP-3
    • IgG
    • IgG1
    • IgG2
    • IgG3
    • IgG4
    • IgM
    • IL1
    • IL10
    • IL11
    • IL12
    • IL12b (IL23p40)
    • IL12p70
    • IL13
    • IL15
    • IL16
    • IL17
    • IL17a
    • IL17af
    • IL17F
    • IL18
    • IL18 BPa
    • IL18BP (Interleukin-18 Binding Protein)
    • IL19
    • IL1a
    • IL1b
    • IL1RA (Interleukin-1 Receptor Antagonist)
    • IL2
    • IL20
    • IL21
    • IL22
    • IL23
    • IL24
    • IL25
    • IL26
    • IL27
    • IL28a
    • IL29
    • IL3
    • IL31
    • IL32
    • IL33
    • IL34
    • IL35
    • IL36
    • IL37
    • IL4
    • IL5
    • IL6
    • IL7
    • IL8
    • IL9
    • Immune complexes (IC)
    • Immunoreactive LTC4 (iLTC4)
    • Interferon (IFN)
    • Interferon Alpha (IFNa)
    • Interferon Alpha 2 (IFNa2)
    • Keratinocyte growth factor
    • LDL-cholesterol
    • Leptin
    • LIF (leukemia inhibitory factor)
    • LIGHT (TNFSF14, CD258)
    • Linoleic Acid
    • Lipocalin-2
    • LTB4
    • LTC4
    • LTD4
    • LTE4
    • Lysozyme
    • Mast cell chymase
    • Mast cell tryptase
    • MCSF
    • MDA (malondialdehyde)
    • MIF
    • MMP1
    • MMP10
    • MMP12
    • MMP2
    • MMP8
    • MMP9
    • MSPa (macrophage stimulating protein a)
    • MUFA (Monounsaturated Fatty Acids)
    • Nerve Growth Factor (NGF)
    • Neurofilament light chain
    • Neuropeptide Y
    • Neutrophil elastase
    • NLRP3 (Nod-like receptor protein 3 inflammasome)
    • NO
    • Non-HDL-unesterified cholesterol
    • Oleic Acid
    • Oncostatin-M
    • ONOO (Peroxynitrite)
    • Osteocalcin
    • Osteopontin (OPN)
    • PARC (recombinant human MIP-4)
    • PDGF-bb
    • PDGF-АА
    • Pentraxin-3
    • Perforin
    • Periostin
    • PGE1
    • Phosphatidylcholine
    • Plasmin-alpha2-plasmin inhibitor complex (PIC)
    • Plasminogen
    • Plasminogen activator inhibitor-1 (PAI-1)
    • Platelet-Activating Factor (PAF)
    • Procalcitonin
    • Prostaglandin D2
    • Prostaglandin E2 (PGE2)
    • Prostaglandin F2b (PGF2b)
    • Prostaglandin F2α (PGF2α)
    • Protein carbonyls
    • Protein total
    • P-tau (phosphorylated tau)
    • PUFA (Polyunsaturated Fatty Acids)
    • Resistin
    • Retinol-binding protein (RBP)
    • RF (Rheumatoid Factor)
    • RIPK1 (receptor-interacting protein kinase-1)
    • sAbetaPPbeta
    • sCD163
    • sCD23
    • sCD27
    • sCD30
    • sCD40L
    • Secretory Leukocyte Protease Inhibitor (SLPI)
    • Selenium
    • Serum amyloid A
    • SFA (Saturated Fatty Acids)
    • Sgp130 (Soluble Glycoprotein 130)
    • sIL1R1 (Soluble Interleukin-1 Receptor-1)
    • sIL1R2 (Soluble Interleukin-1 Receptor-2)
    • sIL1R3 (Soluble Interleukin-1 Receptor-3)
    • sIL1R4 (Soluble Interleukin-1 Receptor-4)
    • sIL2R
    • sIL2Ra (Soluble Interleukin-2 Receptor subunit alpha)
    • sIL6R
    • sIL7R
    • sILT3
    • Sphingomyelin
    • Squamous cell carcinoma antigen (SCC)
    • sST2 (Soluble suppression of tumorigenicity-2)
    • Stem Cell Factor (SCF)
    • sTNF-R1
    • sTNF-R2
    • sTREM2 (soluble triggering receptor expressed on myeloid cells 2)
    • Substance P (SP)
    • SuperOxide Dismutase (SOD)
    • Surfactant protein (SP-A)
    • sVEGFR1
    • sVEGFR2
    • Taurine
    • TGFa
    • TGFb
    • TGFb1
    • TGFb2
    • TGFb3
    • Thioredoxin 1 (TRX1)
    • Thrombin-antithrombin complex (TAT)
    • Thromboxane B2 (TXB2)
    • Thyroglobulin (TG)
    • Tim-3 (HAVCR2)
    • TIMP1
    • TIMP2
    • Tissue factor
    • Tissue Plasminogen Activator (tPA)
    • Tissue plasminogen activator (tPA)/plasminogen activator inhibitor type I (PAI) complex (tPA/PAI)
    • TNFa
    • TNFb
    • Total cholesterol
    • Transferrin
    • Triglyceride
    • Troponin T
    • Tryptase
    • TSLP
    • T-tau (total tau)
    • TWEAK
    • Unesterified cholesterol
    • Urate (Urea acid)
    • Urokinase-type plasminogen activator (uPA)
    • VAP-1 (vascular adhesion protein-1)
    • Vascular Endothelial Growth Factor (VEGF)
    • Vasoactive Intestinal Peptide (VIP)
    • VCAM-1 (vascular cell adhesion molecule-1)
    • VEGF-A
    • VEGFC
    • Activated B-cells
    • Activated Eosinophils
    • Activated Tc
    • Activated T-cells
    • Activated Th1
    • Activated switched memory B-cells
    • Apoptotic cells
    • Apoptotic eosinophils
    • Basophils
    • B-cells
    • Bm1-cells
    • Bm2-cells
    • Bm3-cells
    • Bm4-cells
    • Bm5 Early cells
    • Bm5 Late cells
    • Cells
    • Central memory T-cells
    • Columnar epithelial cells
    • Dendritic Cells (DC)
    • Dermal dendritic cells
    • Double-Negative B-cells
    • Double-negative T cells
    • Effector memory T-cells
    • Effector T-cells
    • Eosinophil
    • Epidermal cells
    • Epithelial cells
    • gamma-delta T-cells
    • Germinal Center B-cells
    • Histiocytes
    • IDEC/IDDC
    • Immature B cells
    • Immune cells
    • Immunocytes(T-cells,B-cells,Mast cells)
    • Inflammatory Dendritic Epidermal Cells (IDEC)
    • Innate lymphoid cells 2 (CRTH2+)
    • Invariant natural killer T-cell
    • Langerhans Cells (LC)
    • Lymphocytes
    • Macrophages
    • Mast cells
    • Mast cells progenitor
    • Mature Dendritic Cells (DC)
    • Mature Langerhans cells
    • Memory B-cells
    • Memory regulatory T-cells
    • Memory Tc-cells
    • Memory T-cells
    • Memory Th1-cell
    • Metachromatic cells (mast cells and basophils)
    • Monocytes
    • Monocytes/macrophages
    • Monocytic Myeloid-Derived Suppressor Cells (M-MDSC)
    • Mononuclear cells
    • Myeloid cells
    • Myeloid Dendritic Cells (mDC)
    • Myeloid Dendritic Cells 1 (mDC1)
    • Myeloid Dendritic Cells 2 (mDC2)
    • Myeloid-Derived Suppressor Cells (MDSC)
    • Naive B-cells
    • Naive regulatory T-cells
    • Naive Tc-cell
    • Naive T-cells
    • Naive Th1
    • Naive Th-cells
    • Natural Effector B-cells
    • Natural Killer cells (NK)
    • Natural killer T-cells
    • Neutrophil
    • Neutrophils Nonsegmented
    • Neutrophils Segmented
    • NK1
    • NK17
    • NK2
    • Non-memory B cells
    • Non‐switched memory B-cells
    • Pan-leukocytes
    • PBMC (Lymphocytes and Monocytes)
    • PD-L1+ Cell
    • Peripheral blood monocytes
    • Peripheral blood mononuclear MDSCs (PMN-MDSCs)
    • Plasma B-cells
    • Plasmablasts
    • Plasmacytoid Dendritic Cells (pDC)
    • Platelets
    • Precursor neutrophils
    • Precursor of Germinal Center B-cells
    • Red blood cells
    • Resting class-switched memory B-cells
    • Resting neutrophils
    • Sensory Nerve Endings
    • Squamous cells
    • Switched memory B-cells
    • Tc17-cell
    • Tc1-cell
    • Tc22-cell
    • Tc2-cell
    • Tc-cells
    • T-cells
    • Teff/Treg cell
    • Th0-cells
    • Th17-cells
    • Th1-cells
    • Th22-cells
    • Th2-cells
    • Th9-cells
    • Th-cells
    • TIP-DC (TNF and iNOS-producing dendritic cell)
    • Total cell count
    • Transitional B cells
    • Treg-cells
    • White Blood Cells (WBC)
  • 13755 values of cytokine/cell concentrations;
  • data extracted from 527 papers/other public sources.

CYTOCON DB Open is developed as a web application based on the ASP.NET MVC framework. It works under Microsoft IIS web server. The data warehouse is a Microsoft SQL Server database. The user interface application is implemented using Telerik Kendo UI and Bootstrap.

Access to Cytocon DB Open

To start working with CYTOCON DB Open use following credentials:

Login: user1

Password: 12345678

e-mail for correspondence: cytocon@insysbio.com